Craig Hignett will be without skipper Ryan Donaldson and midfielder Nicky Featherstone after both players were sent-off on Saturday and begin two-game suspensions.
The Pools boss has no new injury worries ahead of the clash with The Spireites, with Fraser Kerr still on the sidelines with a foot problem picked up in last weekend’s game at Dagenham & Redbridge.
Myles Anderson (concussion) and Niko Muir (hamstring) are both still doubts, while Luke Molyneux (foot) and Luke Williams (knee) remain out following surgery.
Chesterfield boss John Sheridan is expected to make changes to his starting line-up following their disappointing 4-0 defeat at Sutton United on Saturday.
Tom Denton didn’t start at Gander Green Lane over concerns about the artificial surface but the front man could come in to contention for a return against Pools.
Sheridan will also check on the fitness of Anthony Gerrard and Anthony Spyrou who have both missed The Spireites’ recent games through injury.