Craig Harrison's side battled back from 2-1 down to take a point from the Boxing Day fixture with Gateshead at the International Stadium.
Liam Donnelly had given Pools a first-half lead but Gateshead took quick advantage once Blair Adams had been harshley sent off just before the break to draw level.
The hosts took the lead shortly after half time but Michael Woods got an equaliser for Pools mid-way through the half and Harrison's side battled hard to hold on to the point.
Gateshead threatened with a couple of early punts from distance to show Pools their intent, with Wes York looking liveliest for the hosts.
Pools soon settled into their stride though and were in action at the right end of the pitch, with the breakthrough coming around the quarter-hour mark.
Michael Woods threw himself into the challenge to win the ball back for Pools, allowing Lewis Hawkins to lift one up into the box for Rhys Oates to meet. But as Oates pulled away to try and get his shot in, he was tripped by the defender and the referee Andrew Miller pointed straight to the penalty spot.
There was a delay before the penalty could be taken as Woods received treatment to head injury but Liam Donnelly kept his cool and stepped up to slot the ball into the bottom corner and give Pools an 18th-minute lead.
Oates got through again just after the goal, running free of the defender to send a low drill at goal but it was too easy for Dan Hanford in the Gateshead goal.
At the other end, Donnelly put a great block in to deny York who got into the box to fire another shot at goal just before York once again got into a good position to shoot but dragged his effort wide of the far post.
Luke Hannant fired a shot in from distance that was blocked by Scott Loach and Blair Adams reacted quickest to boot clear the rebound.
And that was the last of the action for Adams in the game as the full back picked up a second yellow card shortly after for an innocent-looking challenge and he was sent off, reducing Pools to ten men.
That wasn’t the final blow for Pools in this first half though as Gateshead grabbed an equaliser right on half time; a well-worked corner routine found Scott Barrow arrive 25 yards out on goal where he powered a strike through the box and into the bottom corner to make it 1-1.
With just five minutes of the second half having been played, Gateshead were 2-1 up and the goal was a replica of the first; a corner routine clearly practiced on the training ground picked out Barrow 25 yards out on goal and once again he was allowed to smash an effort through the area to put the hosts ahead.
Ten-man Pools now needed to find a spark from within the ranks to get anything from this derby game.
The goal took a while to come for Pools who had to be very patient and spent much of the second half working to defend their goal but thankfully it did arrive.
It was good work from Louis Laing to start the move, Hawkins worked hard down the right and then Rodney put a great ball into the box for Woods who finished calmly past Hanford to make it 2-2 on 72 minutes.
A Nicky Deverdics corner just before the 80th minute was flicked on by Hawkins at the near post but the ball flashed across the goal without a crucial touch that could have put Pools ahead.
With neither side looking happy to settle for a point, Pools had to remain strong at the back but also offered more of the threat going forward.
And a great run down the right by Devante Rodney opened things up for Pools, the young winger pushed in to smash a shot at goal which was well-saved by Hanford. The rebound came out to Woods running into the box but his strike was blocked by the defender and Gateshead were able to clear the danger.
It was a tense finish here at the International Stadium and Pools had to battle hard to keep the hosts at bay, with Gateshead keeping Harrison’s men pinned back and Scott Loach came to the rescue on 90 minutes with a wonder save. The keeper somehow kept a Danny Johnson effort out with a great block with his legs to keep things at 2-2.
But ten-man Pools fought hard to hold on to the point and the game finished 2-2, bringing to an end a run of 5 defeats for Harrison's side.
Full Time: Gateshead 2 Pools 2
Attendance: 3538 (2185 Pools)
Booked: Adams (33), Cassidy (58), Donnelly (70)
Sent Off: Adams (41)
Gateshead: Hanford, Tinkler, Kerr (Vassell 49), Byrne, Barrow, York (McLaughlin 67), Penn (Preston 81), Hannant, Peniket, Burrow, Johnson.
Subs Not Used: Montgomery, Williams.
Pools: Loach, Adams, Donnelly, Laing, Deverdics, Hawkins, Woods, Franks, Rodney (Watson 90), Cassidy, Oates.
Subs Not Used: Munns, Thorne, Simpson, Adeloye.