Pools Reserves' game against Chesterfield on Wednesday afternoon (2pm kick-off) will now take place at Billingham Town.
It had originally been scheduled to be played at Victoria Park but the Club have now confirmed the switch in venue.
The opening fixture of the campaign sees Micky Barron's men take on the Spireites in the new Divisional section of the Central League competition.
Meanwhile, the Reserves' trip to Tranmere Rovers has been brought forward by 24 hours and will now be played on Tuesday 16th October (7pm kick-off).