Goals from Antony Sweeney and Ryan Noble gave Pools their first win at Victoria Park since 18th February.
The victory over League One strugglers Leyton Orient gave Neale Cooper's men their first League win in 6 matches and gave the home fans a more positive finale to the season at The Vic.
The first half here at The Vic was a fairly even affair, with neither team taking full control of proceedings.
But it was Pools who first stepped up to test the keeper as a Neil Austin freekick sailed into the area and Peter Hartley rose to challenge but Jamie Jones in the away goal did enough to keep the defender's effort out.
Scott Flinders at the other end pulled off a much more impressive block to deny Kevin Lisbie later in the half; with the Orient striker shooting at goal from just a couple of yards, the Pools keeper blocked brilliantly to deny the goal.
With 23 minutes on the clock Pools, who were looking the brighter, opened the scoring through Antony Sweeney.
In a move started by Andy Monkhouse in the middle of the field as he set Neil Austin running down the right, the ball eventually found its way into the area where it took another touch off Monkhouse before finding Sweeney who finished into the roof of the net from close range.
Darren Holden, making his first start of the season, showed bright signs down the left this afternoon, carrying on the form shown in his appearance as sub last weekend at Tranmere.
Pools set off on another attack - this time it was Noble who set Monkhouse away down the left and the winger did well to push level with the area. And with only Sweeney to aim for in a crowded box, Monkhouse picked him out but the ball was moving at pace and the final shot went wide of goal.
But with Pools having looked relatively comfortable to this point, Orient pulled level just after the half hour mark - with the lively Jamal Ryce-Campbell grabbing the goal.
A slip in midfield allowed Lisbie to break forward with the ball and he fed the pacu Ryce-Campbell who pushed into area under pressure from jack Baldwin and sent a low strike into the far corner of the goal.
The two teams went into the second half all square and Pools had work to do if they were to finish their home campaign on a high.
And Pools started the second period well as a lovely ball upfield from Baldwin for Holden saw the bal played in for Noble but the striker's long-range chipped effort went over the bar.
At the other end, Flinders pulled off another good block as he denied Lisbie running in on goal with a great one-handed block on the edge of his area.
Neale Cooper showed his intentions on the hour mark, bringing the attacking force of Luke James and James Poole into the action to try and spur his side to victory.
But it was the visitors who went on to enjoy the better fortunes for a spell, dealing comfortably with anything Pools had to offer and using the break to win a corner kick.
Andy Monkhouse was the only Pools' player to try his luck on goal but he saw his long-range effort miss target.
But with 73 minutes on the clock Pools, who were looking beginning to look more likely, re-took the lead.
A lovely ball into the box by Evan Horwood from the left found Ryan Noble rising inside the area and the striker sent a glancing header past Jones and into the far corner of the net.
Orient, fighting to ensure they remained out of the relegation zone, battled back at Pools after the goal and with a succession of corners made appeals for a penalty kick before seeing another effort crash against the woodwork.
And Pools spent much of the remainder of the half working hard to hold on to their lead against a battling Orient outfit.
But hold on Cooper's men did to bring this current home campaign to a close with a much-needed and long-awaited victory.
Att: 4502 (230 Leyton Orient)
Pools: Flinders, Austin, Baldwin, Hartley, Horwood, Sweeney, Murray (Poole 60), Liddle, Holden (James 60), Noble, Monkhouse
Subs Not Used: Rafferty, Richards, Humphreys
Leyton Orient: Jones, Ben Youssef, Forbes, Chorley, McSweeney, Smith (Mooney 87), Spring, Reed, Cox (Porter 77), Campbell-Ryce, Lisbie
Subs Not Used: Andrew, Cestor, Taiwo